Semaglutide
FDA approved

A medicine that acts on the GLP-1 pathway.
GLP-1 receptor agonist
Commonly explored for
Weight lossFDA Approved
Blood sugarFDA Approved
How it works
- Appetite controlActs on pathways involved in appetite regulation and can reduce food intake.
- Metabolic effectsAlso studied for effects on blood glucose and other metabolic measures.
- GLP-1 pathwaySemaglutide acts on the GLP-1 pathway.
Good to know
Digestive side effects are common
Serious warnings apply
Safety
Potential side effects
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Abdominal pain
Warnings
- Not for everyone. Contraindications and boxed warnings are in official labeling.
- Talk to a licensed clinician before starting, stopping, or changing any medicine.
Evidence
Established clinical evidence (labeled uses)
Large human trials and regulatory reviews support labeled uses. This is not a complete list of indications and is not a recommendation.
Sources
- DailyMed search: semaglutideNIH DailyMed
- FDA Drugs@FDAU.S. Food and Drug Administration
- NIH DailyMedNIH DailyMed
Last reviewed: 2026-08-29
